ReplaceAll[((B/(1 + E/100) + A) (P * 1.25))/(60*(1 + 0.75*((0.15 * R) - (0.011 * R)*(360 - C)/30))), {B -> 10, E ->0, A -> 1.00, P -> 3.5, R -> 0, C -> 360}]

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